Palladium(Ii)-Catalyzed C(Sp)-C(Sp(2)) Coupling: A Direct Approach To Multi-Substituted Pyrrolo[1,2-A]Pyrazines
SYNTHESIS-STUTTGART(2021)
摘要
A direct synthesis of multi-substituted pyrrolo[1,2-a]pyrazines via palladium(II)-catalyzed C(sp)-C(sp(2)) cascade coupling and intramolecular cyclization in the presence of ligand was developed. This reaction originates from phenylboronic acids and readily synthesized 2-carbonyl- or 2-formylpyrroloacetonitriles, and affords products in good to excellent yields for a diversity of substrates. Additionally, a possible mechanism for the transformation is proposed.
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关键词
C-C coupling, palladium, cascade reactions, substituted pyrrolo[1,2-a]pyrazines
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