Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

Highlights Nanoparticles hold considerable promise for controlling the local pharmacokinetics of therapeutic agents during osteoarthritis therapy. The advantages of nanoparticles, the bioactive design, the transports and interactions within cartilage, and therapeutic mechanisms are discussed. This review proposes future strategies to design more intelligent and multi-functional nanomaterials as delivery systems for cartilage therapy.