Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives

Mengfan Zhang,Sandra Serna-Salas, Turtushikh Damba,Michaela Borghesan,Marco Demaria,Han Moshage

Mechanisms of Ageing and Development（2021）

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摘要

•This review discusses the basic mechanism of cell senescence, in particular hepatic stellate cells.•The role of hepatic stellate cell senescence in liver fibrosis is discussed in detail.•Discussion of the potential of inducing stellate cell senescence for therapeutic intervention.

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ECM,MSC,HSC,qHSC,aHSC,iHSC,PF,PDGFRβ,LRAT,GFAP,ACAT2,COL1A1,PPARG,TIMP1,DDR,SA-β-Gal,SAHF,CDKI,CDKN1A,CDKN2A,PCNA,SASP,PAI-1,GFBP7,IL-8,CXCL1,IL-6,H3K4me3,LAD,UPR,ROS,SSB,DSB,MRN complex,ATM,ATR,CHK1,CHK2,PARP,NF-κB,C/EBPβ,IKK,NIK,PI3K,GSK3,FOXO,TSC2,SOD2,mTOR,mTORC1,mTORC2,S6K1,4EBP,PGC1α,NAD,CMA,HSC70,LAMP2A,NEF2L2,PLP,CBS,CTH,KEAP1,STAT3,G-CSF,EIF2AK2,SOSC3,AR,CaM,CCl4,NAFLD,LSEC,uPAR,CAR,cGAS,STING,CCF

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