Comparing The Effect Of Risperidone, Virtual Reality And Risperidone On Social Skills, And Behavioral Problems In Children With Autism: A Follow-Up Randomized Clinical Trial
ARCHIVES OF IRANIAN MEDICINE(2021)
摘要
Background: Improving behavioral and social problems in children with autism requires extensive training programs even with parents at home. The main goal of this study is to design a virtual reality (VR) intervention based on the TEACCH method in combination with risperidone to evaluate its effectiveness on social and behavioral problems. Methods: Forty-three children with autism (6-12 years old) randomly were divided into three groups: risperidone (n = 15), risperidone + VR (n = 15), and control (n = 13). The interventions lasted for 3 months (90 sessions) and post-test assessments were done immediately after intervention. Follow up tests were done 3 months after that. Results: Risperidone + VR group showed significant differences in social skills (MD = 36.59; 95% CI: 30.74 to 38.42, P < 0.001, g2 = 1.51 in post-test; MD = 19.63; 95% CI: 17.27 to 21.63, P < 0.001, g2 = 0.86 in follow up); and behavioral symptoms (MD =-36.12 ; 95% CI:-39.72 to-36.91, P < 0.001, g2 = 1.99 in post-test; MD =-28.82 ; 95% CI:-29.43 to-25.32, P < 0.001, g2 = 1.58 in follow up) compared to the control group. However, the risperidone group showed significant differences in social skills (MD = 2.03; 95% CI: 0.82 to 3.67, P < 0.001, g2 = 0.12) and behavioral symptoms (MD =-36.66; 95% CI:-38.96 to-34.27, P< 0.001, g2 = 1.96) only in post-test. Thus, the experimental groups did not have any significant difference in post-test. Conclusion: Combined interventions such as VR can enhance the effectiveness of risperidone response and boost children's preparedness to practice and learn social interaction.
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关键词
Autism spectrum disorder, Behavioral problems, Risperidone, Social skills, Virtual reality
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