Long-Term Outcome In Children And Adolescents With Chronic Myeloid Leukemia In Chronic Phase Treated With High-Dose Imatinib- The Italian Experience

The availability of imatinib (IM) and thereafter of second-generation tyrosine kinase inhibitors (TKI2) has extended therapeutic options for childhood chronic myeloid leukemia (CML) with a favorable influence on disease outcome and overall prognosis. The aim of this report was to evaluate the response to therapy and long-term outcome of children and adolescents with CML in chronic phase (CP) treated with high-dose imatinib (IM).