Monitoring Voriconazole Pharmacogenomics And Plasma Concentrations In The Treatment And Prevention Of Invasive Fungal Disease For Chinese Hematological Patients

Background Voriconazole has been widly used in treatment and prevention invasive fungal disease for immunodeficiency hematological patients. And the voriconazole plasma drug levels were associated with its efficacy and toxicity. The hepatic cytochrome P450 isoenzyme 2C19 plays a important role in voriconazole metabolism. However if CYP2C19 genetic polymorphism can result in voriconazole metabolism and drug plasma level in setting of Asian population especially in hematologic patients is unknown.