Value Of Rdw And Plr Levels In Evaluating The Prognosis Of Sepsis Combined With Acute Kidney Injury

Objective: To study the value of red blood cell volume distribution width (RDW) and platelet-to-lymphocyte ratio (PLR) levels in evaluating the prognosis of sepsis combined with acute kidney injury.Methods: 120 patients with sepsis combined with acute kidney injury (AKI) admitted to the ICU in our hospital from July 2018 to July 2019 were collected and divided into a survival group (n = 74) and a death group (n = 46), according to the prognosis of patients. The healthy people in the examination center of our hospital during the same period were selected as the control group (n = 30). From all of the subjects, 5 ml of fasting venous blood were collected, and the platelet count (PLT), lymphocyte count (LYM), and RDW levels were detected by an automatic biochemical analyzer. The lactate level was monitored by the tomato sauce L/D-lactic acid test, and the platelet-to-lymphocyte ratio (PLR) was calculated to explore the value of the RDW and PLR levels in evaluating the prognosis of sepsis combined with acute kidney injury.Results: The temperatures, heart rates, respirations, WBC, and neutrophil counts of patients in the survival and death groups were higher than those of the control group. In addition, the systolic and diastolic blood pressures were significantly lower than those of the control group, and the difference was statistically significant (P<0.05). The temperatures, heart rates, respirations, WBC, systolic blood pressures, diastolic blood pressures, and centriole counts of the survival group were not significantly different from those of the death group (P>0.05). The PLT and LYM levels in the survival group were significantly lower than those of the control group and the death group, and the death group were significantly lower than the control group. The PLR and PDW levels in the death group were significantly higher than those of the control group and the survival group, and the survival group was significantly higher than that of the control group, the difference was statistically significant (P<0.05). In all patients with sepsis combined with AKI, using survival/death (0/1) as the dependent variable, a logistic regression analysis of PLT, LYM, PLR and PDW showed that PLR, RDW, and PLT were all related to the prognosis of patients with sepsis combined with AKI (P<0.05). An ROC curve analysis showed that the AUC of the prognosis of patients with sepsis combined with AKI judged by PLR was 0.895, and the best diagnostic value was 120. The sensitivity of this diagnosis value was 83.56%, and the specificity was 81.44%. In addition, the AUC of the prognosis judged by RDW was 0.862, and the best diagnostic value was 0.16. The sensitivity of the diagnostic value was 80.00%, and the specificity was 79.56%. The AUC of RDW combined with PLR to determine the prognosis of sepsis patients with AKI was 0.908, the sensitivity was 89.26%, and the specificity was 87.59%. To conclude, the serum RDW and PLR levels in patients with sepsis combined with AKL were higher than those in healthy people, which could have a certain value in evaluating the prognosis of patients with sepsis combined with AKI, of which RDW combined with PLR is the most valuable.