Interim Analysis Of A Multicenter Randomized Controlled Trial Comparing The Right Colon Adenoma And Serrated Polyp Miss Rates With Colonoscopy Using Water Exchange And Carbon Dioxide Insufflation

Missed lesions contribute to post-colonoscopy colorectal cancer (PCCRC). Single-center randomized controlled trials (RCTs) (JCG 2020 [in press]; GIE 2020;91:AB108) showed a significant reduction in right colon adenoma miss rate (rAMR) using water exchange (WE) compared to carbon dioxide (CO2) or air insufflation. Generalizability of these results awaits confirmation by a multicenter trial. We are conducting a prospective multicenter RCT to test the hypothesis that WE produces a significantly lower rAMR and right colon serrated polyp miss rate (rSPMR) than CO2 insufflation. We report a preplanned interim analysis at 50% enrollment approved by the institution review board.