Antidiabetic And Antilipidemic Effect Of Clerodendrum Paniculatum Flower Ethanolic Extract. An In Vivo Investigation In Albino Wistar Rats

Background and purpose of the study: The goal was to evaluate the effects of ethanolic extract of Clerodendrum pan-iculatum flower (CPF) on antidiabetic and antilipidemic tests indices of experimentally-induced hyperglycemic rats.Methods: High Fat Diet (HFD) treated Streptozotocin (STZ) induced diabetic rats were used for this study. The acute toxicity of ethanolic extract of C. paniculatum flower (2000 mg/kg body weight) and antidiabetic effect of CPF (200 mg/kg body weight)were studied in rats. Glibenclamide (1.25 mg/kg body weight) was used as a reference drug. For antihyperglycemic evaluation, glucose, C-peptide, Insulin, Haemoglobin and glycosylated haemoglobin(HbA1c) levels were analyzed. Low density lipoprotein (LDL), High density lipoprotein(HDL), triglycerides and total cholesterol were analyzed in rats. The enzymic antioxidant activity (super oxide dismu-tase(SOD), glutathione peroxidase(GPx), glutathione S transferase (GST) and Catalase) and non-enzymic an-tioxidant activity(vitamin C, vitamin E and reduced glutathione) of C. Paniculatum flower were evaluated. Im-portant carbohydrate metabolizing enzymes like Glucose 6-phosphatase, Fructose 1and 6 diphosphatase and hexokinase were determined in experimental rats.Results: After the oral administration of CPF extract significantly reduced glucose levels and cholesterol values. Extract improved enzymic and non enzymic antioxidant levels.Conclusion: CPF extract is useful in controlling blood glucose level as well as improving lipid metabolism and body weight in rats with induced diabetic rats.