Large Genomic Alterations Occurring In The Transition From Chronic To Blast Phase Of Chronic Myeloproliferative Neoplasms
BLOOD(2018)
摘要
INTRODUCTION Five to 20% of patients with myeloproliferative neoplasms (MPN), including Essential Thrombocythemia (ET), Polycythemia Vera (PV) and Primary Myelofibrosis (PMF), transform to an aggressive secondary acute myeloid leukemia (sAML). While several studies reported the association of some mutations with the risk of leukemic transformation (Vannucchi AM et al, Leukemia 2013), the mechanisms that contribute to transformation from MPN to sAML remain largely poor characterized.
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关键词
chronic myeloproliferative neoplasms,large genomic alterations,blast phase
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