Efficacy And Safety Of Hydroxyurea In The Treatment Of Sickle Cell Anemia Children In Jos, North Central Nigeria

Introduction: Sickle Cell Anaemia (SCA) is a genetic disorder with significant morbidity and mortality, and Nigeria accounts for the highest burden of the disease worldwide. Hydroxyurea has been shown to positively modify the disease pathogenesis, but its use is low among Nigerian SCA patients because of efficacy and safety concerns. Hence, this study evaluated the efficacy, tolerability and safety of hydroxyurea in Nigerian children with SCA.