Clonal Hematopoiesis And Inflammation In Obesity

H. Tercan,R. C. Van Deuren,K. Schraa,R. Ter Horst, I. C. Van Den Munckhof,S. Bekkering, J. H. Rutten,M. G. Netea,L. A. B. Joosten,A. Hoischen,N. P. Riksen

ATHEROSCLEROSIS（2021）

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摘要

Background and Aims: Obesity is a risk factor for atherosclerotic cardiovascular disease (CVD) and is associated with chronic low-grade inflammation. Recently, clonal hematopoiesis has emerged as a novel risk factor for CVD. We hypothesize that clonal hematopoiesis is a cardinal driver of inflammatory processes in patients with obesity, especially with advancing age, which subsequently leads to development of CVD.

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clonal hematopoiesis,obesity,inflammation

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