Combination of photothermia and magnetic hyperthermia properties of Fe3O4@Ag hybrid nanoparticles fabricated by seeded-growth solvothermal reaction

In this work, the monodisperse Fe3O4@Ag core-shell hybrid nanoparticles (NPs) with an average size of 16.0 nm have been successfully fabricated by the seeded-growth method in the organic solvent. The influence of the molar ratios of AgNO3/OLA on the formation of hybrid NPs has been investigated in detail to find the optimal conditions for the synthesis of the desired Fe3O4@Ag hybrid NPs. The hydrophobic Fe3O4@Ag hybrid NPs were successfully transferred into the water using poly (maleic anhydride-alt-1-octadecene) (PMAO). The PMAO coated Fe3O4@Ag nanoparticles were well dispersed and stable in water over a wide range of pH from 2 to 11 as well as reasonable electrolyte concentration. The Fe3O4@Ag magneto-plasmonic design can efficiently combine magnetic hyperthermia into an effective bimodal thermo-therapy.