Comparative Study Of Trypanosoma Brucei Brucei Infection In Rabbits And Guinea Fowls
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS(2021)
摘要
Trypanosoma brucei is one of the most pathogenic species of the genus Trypanosoma, and T. brucei brucei is one of the subspecies that is of great economic concern to animals. A large range of labouratory animals are commonly used in Trypanosoma studies. This study is aimed at exploring the possibility of using guinea fowls as experimental models for future studies and preservation of T. b. brucei. In achieving our aim, we studied the infectivity and pathogenicity of T. b. brucei in guinea fowls in relation to rabbits. The level of parasitaemia, mean body weight, mean temperature, haematological and histopathological parameters were accessed. Ten each of rabbits (Oryctolagus cuniculus) (control model) and guinea fowls (Numidia meleagris) (study model) (5 in the uninfected groups and 5 in the infected groups) were used for this study. The infected rabbits were inoculated intraperitoneally, while the infected guinea fowls were inoculated through the wing veins. Both animals were inoculated with 0.20 ml of T. b. brucei-infected blood estimated to be 1x 10(6) parasites/ml. The infected rabbits and guinea fowls were screened daily for the presence of T. b. brucei using the haematocrit centrifugation technique (HCT). The mean weight, mean temperature and haematological parameters were accessed weekly, while the histopathological parameters were accessed at the end of the study. Trypanosoma b. brucei was detected in the blood of infected rabbits about 8 days post-infection, while there was no parasitaemia in the infected guinea fowls. The haemoflagellate exerted a significant (p < 0.05) effect on the mean body weight, mean temperature and haematological parameters of rabbits compared to guinea fowls. The pathological effects of T. b. brucei infection was seen in the liver and kidney of infected rabbits, and in the spleen of infected guinea fowls. There appears to be no successful multiplication and proliferation of T. b. brucei in the guinea fowls, making it not to be a suitable animal model for experimental studies and preservation of T. b. brucei.
更多查看译文
关键词
Experimental animals, Haematology, Parasitaemia, Pathology, Trypanosoma brucei brucei
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要