Landscape of RB1 alterations in 22,432 Chinese solid tumor patients.
CANCER RESEARCH(2022)
Abstract
Our findings indicate that alterations are widely distributed in solid cancers of many different histotypes in China, with specific mutations differing largely among different tumor types. The present study provides a comprehensive landscape of mutations in Chinese solid tumor patient and suggests a novel therapeutic target for cancer treatment.
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Key words
Retinoblastoma susceptibility gene (RB1),cyclin-dependent kinase 4/6 inhibitor,next-generation sequencing (NGS),resistance,solid tumor
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