Effects Of Different Blood Purification Techniques On Interleukin-28 And Mineral Levels In Patients

Objective: To investigate the effects of different combinations of blood purification techniques on interleukin-28 and mineral levels, and the effects of these combinations on the incidence of mineral and bone disorder (MBD) and inflammatory reaction in maintenance hemodialysis patients. Materials and methods: A total of 150 maintenance hemodialysis patients were divided into the hemodialysis group (HD group, n = 51), hemodialysis plus hemodiafiltration group (Group A, n = 56), and hemodialysis plus hemoperfusion group (Group B, n = 43). The changes of interleukin-28 (IL-28), calcium (Ca), phosphate (P), intact parathyroid hormone (IPTH), fibroblast growth factor 23 (FGF-23), beta-cross-linked C-telopeptide of type 1 collagen (beta-CTX), and procollagen type 1 N-terminal propeptide (P1NP) in three groups were evaluated. Results: The IL-28 and P levels were significantly increased in HD group after 6 months of treatment (P < 0.05). A significant decrease was found in IPTH levels in the Group A (P < 0.05), while a significant decrease in IL-28, IPTH, beta-CTX, P1NP, and FGF-23 levels was noted in Group B (P < 0.05). IL-28, P, IPTH, beta-CTX, P1NP, and FGF-23 levels in Group B were lower than that in HD group (P < 0.05). The number of patients with MBD and inflammatory reaction increased in the HD group. Conclusions: Hemodialysis plus hemodiafiltration is more effective than hemodialysis alone in the improvement of MBD and the inflammatory reaction; hemodialysis plus hemoperfusion has a stronger impact on the improvement of MBD.