Tumor Budding As A Prognostic Marker In Stage Iii Colorectal Carcinoma

Tumor budding is a characteristic microscopic feature representing tumor dedifferentiation at the invasive front of the tumor. Its clinical significance lies in simplicity in detection using the conventional hematoxylin-eosin (HE) staining without specific and/or cost-demanding techniques and its superior reproducibility.Intensity of tumor budding at the invasive tumor margin is suggested to be a good pathologic variable to estimate malignancy potential in patients with colorectal carcinoma (CRC).