Development Of A Multi-Kilogram Procedure To Prepare, Use, And Quench Ethyl Diazoacetate

James H. Simpson,Atul S. Kotnis,Rajendra P. Deshpande,David J. Kacsur,Jason Hamm, Gus Kodersha,William Merkl, Daniel Domina,Steve Y. Wang

MANAGING HAZARDOUS REACTIONS AND COMPOUNDS IN PROCESS CHEMISTRY（2014）

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Abstract

A practical, high yielding procedure for the efficient preparation of toluene solutions of ethyl diazoacetate (EDA) from ethyl glycinate is described. The process incorporates extensive safety studies related to the preparation and handling of a carcinogenic and explosive reagent. In addition, a safe neutralization process for the excess EDA and waste streams were developed. EDA was successfully made as a solution in toluene from three 175-kg batches of ethyl glycinate.

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