Expression Of Much Gene Products In Laryngeal Squamous Cancer
OTOLARYNGOLOGY-HEAD AND NECK SURGERY(2004)
Abstract
OBJECTIVE. Mucins are high-molecular-weight glycoproteins present at the outer surface of mammalian cells. The objective of this study was to examine the expression of mucin (MUC) genes 3, 4, 5AC, 513, 6, and 7 in early and late laryngeal squamous cancer using the in situ hybridization technique.STUDY DESIGN: Retrospective analysis of pathological archive specimens.RESULTS: While MUC 3 and 7 are expressed in a small proportion of early cancers, MUC 5AC, 513, and 6 are not expressed in laryngeal squamous cancer. MUC 4 was expressed in 13 of the 30 patients. Ten patients and 3 patients with stage I and stage 4 disease respectively expressed MUC 4 gene (Fisher's exact, P = 0.02). MUC4-positive patients had a definite trend towards better survival (log rank test, P = 0.05). In the presence of tumor stage and comorbidity grade, Cox's proportional hazards model failed to statistically confirm the survival advantage provided by MUC 4 gene expression.CONCLUSION: There is a survival advantage for patients with advanced-stage nonmetastatic cancer when the MUC 4 gene is expressed.AIMS: To study the expression of mucin (MUC) genes 3, 4, 5AC, 513, 6, and 7 in early and advanced squamous cell cancer of the larynx; to attempt to correlate changes in gene expression with tumor stage by studying stage I and stage IV (AJCC, 1988) tumors.
MoreTranslated text
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined