Association Between Cox-2 G-765c Polymorphism And The Risk Of Alzheimer'S Disease: A Meta-Analysis

Background and object: The morbidity rate of Alzheimer's disease (AD) has been increasing with the progression of population aging globally, so the burden of the disease is showing an upward tendency. During the research on AD, COX-2 gene G-765C polymorphism has been explored its function in the susceptibility to this disease, but no consensus was reached. Therefore, we performed this meta-analysis with the hope of obtaining a clearer opinion on this topic. Methods: 7 eligible articles were retrieved from online databases. Odds ratios (ORs) and their 95% confidence intervals (95% CIs) were calculated to assess the strength of the association between COX-2 gene G-765C polymorphism and AD susceptibility. Inter-study heterogeneity was inspected with Q test, and sensitivity analysis was performed to verify the stability of pooled results. Additionally, publication bias between included studies was detected using both Begg's funnel plot and Egger's test. Results: COX-2 gene G-765C polymorphism decreased the risk of AD under five genetic comparisons of CC vs. GG, CC+GC vs. GG, CC vs. GG+GC, C vs. G and GC vs. GG, and a similar trend was also revealed in Caucasian and other-ethnicity groups after stratification analysis of ethnicity under corresponding contrasts. Conclusion: The C allele of the G-765C polymorphism in the COX-2 gene may provide protection against AD onset.