Inkjet-Printed Neural Electrodes With Mechanically Gradient Structure
ACS APPLIED BIO MATERIALS(2019)
Abstract
Flexible materials are important for the development of neural probes in recording stable signals (spikes) in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(D,L-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 mu m-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus in vivo.
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Key words
polymer nanofilm, inkjet printing, printed electronics, neural electrode, optogenetics
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