Proteomics For Diagnostic And Therapeutic Blood Biomarker Discovery In Schizophrenia And Other Psychotic Disorders

This chapter gives an overview of the proteomic techniques currently in use for proteomic profiling of biospecimens from individuals suffering from psychotic disorders such as schizophrenia or bipolar disorder. Discovery and targeted mass spectrometry techniques are introduced and compared with antibody-based proteomic profiling platforms, highlighting the strengths and weaknesses of each approach. Recent findings in the field of blood biomarkers for drug-naive psychotic disorders are reviewed and considered in the context of future potential for personalized psychiatry.