Tnf-Alpha And Il-18 As Diagnostic Markers For Acute Myocardial Infarction (Ami) And Risk Factors For Ami-Related Death

Background: This study aimed to explore the diagnostic values of tumor necrosis factor-alpha (TNF-alpha) and interleukin-18 (IL-18) in acute myocardial infarction (AMI). Methods: We recruited 48 patients with AMI at our hospital as the experimental group and 39 healthy examinees as the control group. Both groups were tested for serum TNF-alpha and IL-18 expressions using enzyme-linked immunosorbent assays and were analyzed for the diagnostic values of the TNF-alpha and IL-18 expressions for AMI using receiver operating characteristic (ROC) curves. Additionally, we explored the risk factors for AMI-related death using logistic regression. The experimental group had higher TNF-alpha and IL-18 expression levels compared with the control group (P < 0.05). According to the ROC curves, the cutoff values, sensitivities, and specialties for the AMI diagnosis were 0.679 pg/mL, 92.31%, and 70.83% for TNF-alpha and 133.50 pg/mL, 89.74%, and 68.75% for IL-18. Results: A multivariate analysis of survival revealed that the Killip classification, heart rate, and TNF-alpha and IL-18 levels were independent risk factors for AMI-related deaths (P < 0.05). TNF-alpha and IL-18 may have participated in the development and progression of AMI with comparatively acceptable sensitivities and specialties in its diagnosis based on their serum expression levels. Conclusions: the Killip classification, heart rate, and TNF-alpha and IL-18 levels are independent risk factors for AMI-related deaths and may be adopted as prediction indexes for evaluating patients' conditions and AMI prognoses.