Negative D-Dimer In Idiopathic Pulmonary Vein Thrombosis: A Case Report And Literature Review

Pulmonary vein thrombosis (PuVT) is a rare but life-threatening thrombotic disease, mostly caused by operation and cancer, while idiopathic PuVT (iPuVT) is rarely reported. Here we presented a 73-year-old man coming for progressive chest pain and dyspnea due to a thrombus occurred in left lower pulmonary vein detected by coronary CTA. After excluded all known causes of PuVT, he was finally diagnosed as iPuVT. Further a systematic review of iPuVT had been conducted to explore their clinical characteristics, and it is unexpected to find that D-dimer were all negative in iPuVT except those complicated with pulmonary artery embolism or myocardial infarction. Therefore, a negative D-dimer cannot reliably exclude iPuVT.