Correlation Between Ankle-Brachial Pulse Wave Velocity And Urine Protein In Patients With Type 2 Diabetes Mellitus

Objective: Urine protein has a close relationship with the occurrence and development of diabetic great vascular complications. This work discusses the correlation between the brachial-ankle pulse wave velocity (baPWV) and urine protein in patients with type 2 diabetes mellitus. Methods: 142 patients with type 2 diabetes mellitus were divided into a normal control group [24 h urinary albumin quantity <30 mg, n=84], micro-albuminuria group [30 mg <= 24 h, urinary albumin quantity <300 mg, n=26], and a clinical proteinuria group (24 h urinary albumin quantity >= 300 mg, n=33) according to the level of 24 h urinary albumin. For all patients with type 2 diabetes mellitus, fasting blood-glucose, blood fat, renal function, glycated hemoglobin (GBALC), pancreatic islet function, C-reactive protein and blood pressure were detected, and body mass index was calculated. Then, baPWV was measured by the autopulse method, and the correlation between baPWV and other factors and the multiple regression analysis were conducted using Pearson correlation coefficient analysis. Results: baPWVs of the micro-albuminuria group and the clinical proteinuria group were 1649.19 +/- 229.36 cm/s and 1759.21 +/- 291.05 cm/s, respectively. Compared with the control group (1522.33 +/- 248.37 cm/s), baPWVs in other two groups accelerated significantly (P<0.05). Pearson correlation analysis showed that 24 h urinary albumin was positively related to baPWV (r=0.347, P<0.01). Multiple linear regression showed that baPWV was correlated with 24 h urinary albumin (P< 0.05). Conclusion: urine protein of patients with type 2 diabetes mellitus is closely related to baPWV.