Expressions Of Vascular Endothelial Growth Factor (Vegf), Platelet-Derived Growth Factor (Pd-Ecgf) And Cyclooxygenase-2 (Cox-2) In Laryngeal Squamous Cell Carcinoma

The aim of this study was to investigate the expressions, significance and correlations of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PD-ECGF) and cyclooxygenase-2 (COX-2) in laryngeal squamous cell carcinoma (LSCC). The expressions of VEGF, PD-ECGF and COX-2 were determined with S-P immunohistochemical analysis in 76 primary LSCC patients and 15 patients with polyp of larynx. The associations of their expressions with pathological and clinical features were statistically analyzed. The positive expression rates of VEGF (63.16%), PD-ECGF (57.89%) and COX-2 (51.32%) in LSCC were significantly higher than those in polyp of larynx (P<0.01). The positive expressions of VEGF, PD-ECGF and COX-2 in LSCC were correlated with the tumor differentiation and invasive depth (P<0.05). The positive expression of VEGF in LSCC was related to lymph node metastasis (P<0.01). There were positive correlations between the expressions of VEGF and COX-2 (P<0.05), PD-ECGF and COX-2 (P<0.01). VEGF, PD-ECGF and COX-2 might play key roles in LSCC. All might have close relations in angiogenesis and might provide new targets for LSCC therapy.