A Unified, Rcm Anchored Approach To Spiro[4.5]Decane-Based Sesquiterpenoids: Collective Synthesis Of (+/-)-Alpha & Beta-Vetispirenes, (+/-)-Beta-Vetivone, (+/-)-Agarospirol And (+/-)-Hinesol

Collective syntheses of five spiro[4.5]decane framework bearing sesquiterpenoids, namely, alpha & beta-vetispirenes, beta-vetivone, agarospirol and hinesol as well as formal synthesis of axenol and gleenol from a readily available precursor cyclohexanone-beta-ketoester via the intermediacy of a versatile intermediate (2,10-dimethylspiro[4.5]dec-1-en-6-one) have been accomplished in a concise manner. (C) 2019 Elsevier Ltd. All rights reserved.