Relationship Analysis Of 25-Hydroxy-Vitamin-D And Parathyroid Hormone In Bone Mineral Density From Senile Osteoporotic Fracture Patients

This study aimed to analyze the relationship between 25-Hydroxy-vitamin-D [25(OH)D] and parathyroid hormone (PTH) with bone mineral density (BMD) in senile osteoporotic fracture. The patients suffered from senile osteoporotic fracture and healthy volunteers were enrolled. Serum 25(OH)D and PTH levels were tested by ELISA. BMD at lumbar 1-4, hip joint, and femoral neck was detected by X-ray absorptiometry. The relationship between 25(OH)D and PTH with BMD was analyzed. Serum 25(OH)D level was lower, while PTH level was higher in experimental group compared with control. BMD at lumbar 1-4, hip joint, and femoral neck was significantly lower in experimental group than the control (P < 0.05). There were 28% patients suffered from severe 25(OH)D deficiency, 32% patients in 25(OH)D deficiency, 23% in 25(OH)D insufficiency, and 17% in 25(OH)D sufficiency. PTH level gradually declined, whereas BMD at lumbar 1-4, hip joint, and femoral neck gradually elevated following 25(OH)D deficiency improvement (P < 0.05). Serum 25(OH)D reduced, while BMD at lumbar 1-4, hip joint, and femoral neck declined in patients with PTH upregulation (P < 0.05). Serum 25(OH)D showed positive correlation with BMD at lumbar 1-4, hip joint, and femoral neck (P < 0.05). PTH presented no statistical correlation with serum 25(OH)D and BMD (P > 0.05). Serum 25(OH)D deficiency and PTH elevation appeared in senile osteoporotic fracture. 25(OH)D was positively correlated with BMD. PTH exhibited no correlation with 25(OH)D or BMD.