Correlation Between Class I Integron And Imipenem Resistance Of Acinetobacter Baumannii: A Systematic Review And Meta-Analysis

The resistance of acinetobacter baumannii to imipenem will significantly increase the clinical mortality of patients. The purpose of this study was to evaluate the value of class I integron in the diagnosis of imipenem resistance of acinetobacter baumannii. We searched Pubmed, Embase, and Web of Science from the establishment of the database to December 2019 for articles of the correlation between class I integron and imipenem resistance of acinetobacter baumannii. The two authors extract and analyze the data independently. A total of 10 papers met the inclusion criteria, including 1269 strains of acinetobacter baumannii isolated from clinical specimens. Among them, 840 strains (66.2%) were class I integron positive and 653 strains (51.5%) were imipenem resistant. Meta-analysis showed that the detection rate of class I integron in imipenem resistant strains of acinetobacter baumannii was significantly higher than sensitive strains [odds ratio (OR) was 3.04, 95% confidence interval (CI) was 2.22-4.18]; The combined sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of class I integron in the diagnosis of imipenem resistance of acinetobacter baumannii were 0.73 (95% CI was 0.70-0.77), 0.39 (95% CI was 0.35-0.43), 1.41 (95% CI was 1.25-1.59), 0.52 (95% CI was 0.37-0.74), respectively, and the area under the summary receiver operating characteristic (SROC) curve was 0.6184. In conclusion, this meta-analysis results suggest that class I integron was related to imipenem resistance of acinetobacter baumannii and it had certain diagnostic values for imipenem resistance of acinetobacter baumannii.