Computational Investigation on Protein Sequence of Non-O157 VTEC for Potentiality of Vaccine Production
2020 IEEE International Conference on Automatic Control and Intelligent Systems (I2CACIS)(2020)
摘要
Computational method can be used for investigation of the protein sequences for developing a vaccine against infections. In this present study, a protein derived from non-O157 Verotoxin-producing E. coli (VTEC) was identified as a potential vaccine candidate that can be used to evaluate their immunogenicity and protective capability against VTEC infections. Identification of potential B-cell epitopes for promising vaccine was carried out by evaluating the protein derived from non-O157 VTEC with the methods of beta turns, hydropathicity, surface accessibility and antigenicity. The methods were implemented in MATLAB. Our test results demonstrated that the VTEC-derived protein has plausible characteristics which provide significant insights for further investigations and will assist in finding potential drug targets/vaccine candidates.
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关键词
Modeling,Protein sequencing,Verotoxin-producing E. coli,B-cell epitopes
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