An Efficient One-Pot Synthesis Of 3,4-Dihydropyrirnidin-2-Ones Catalyzed By Methanesulfonic Acid
SYNTHETIC COMMUNICATIONS（2004）
Abstract
An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aidehydes, beta-ketoesters, and urea in ethanol using methanesulfonic acid (CH3SO3H) as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time.
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Key words
dihydropyrimidin-2(1H)-ones, methanesulfonic acid, synthesis
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