Novel Variants Of The Multicomponent Reaction For The Synthesis Of 1,2,4-Triazolo[1,5-A]Pyrimidines And Pyrido[3,4-E][1,2,4]Triazolo[1,5-A]Pyrimidines
CHEMISTRY OF HETEROCYCLIC COMPOUNDS(2020)
Abstract
A new multicomponent reaction for regioselective synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidines using aminotriazoles, beta-ketoglutaric acid dimethyl ester, and dimethylformamide dimethyl acetal was implemented. The selective reduction of 1,2,4-triazolo-[1,5-a]pyrimidines to dihydro derivatives and the use of triazolo pyrimidines as starting compounds in multicomponent synthesis of dihydropyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidinecarboxylates was demonstrated.
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Key words
acetone-1,3-dicarboxylates, aminotriazoles, dihydropyrido[3,4-e]triazolo[1,5-a]pyrimidines, dimethylformamide dimethyl acetal, 1,2,4-triazolo[1,5-a]pyrimidines, high-resolution HPLC/MS, multicomponent reactions
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