Plasmatic Extracellular Vesicles In Acute Graft-Versus-Host Disease After Haplo-Identical Allografting With Post-Transplant Cyclophosphamide

Giuseppe Lia,Clara Di Vito,Marta Tapparo,Stefania Bruno,Elisa Zaghi,Michela Calvi,Lucia Brunello,Jacopo Mariotti,Lorenzo Comba,Luisa Giaccone,Martina Fasci,Mario Boccadoro,Andrea Evangelista,Luca Castagna,Giovanni Camussi,Domenico Mavilio,Benedetto Bruno

BLOOD（2019）

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摘要

INTRODUCTION: Acute Graft-versus-Host-Disease (aGVHD) is a frequent complication where the endothelium may play a pivotal role. We recently investigated the potential role of extracellular vesicles (EVs) as novel biomarkers of aGVHD (Lia G. et al. Leukemia 2018). In this study we further investigated the correlation of plasma EVs and their content in miRNAs with the risk of developing aGVHD in the setting of post-transplant cyclophosphamide (PTCY) haploidentical-stem cell transplantation (Haplo-SCT).

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plasmatic extracellular vesicles,extracellular vesicles,graft-versus-host,haplo-identical,post-transplant

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