Correlations Of Vegf Expression With Ct Manifestation, Pathology And Prognosis Of Gastric Cancer

Objective: This study aimed to investigate the correlations of VEGF expression with the pathology, computed tomography (CT) features and prognosis of gastric cancer. Methods: A total of 108 gastric cancer patients who received CT examination in our hospital were recruited, and VEGF levels in cancer tissues and cancer-adjacent tissues were measured via immunohistochemistry. The association of VEGF levels with gastric cancer clinicopathological features was assessed. Results: VEGF levels in cancer tissues were significantly increased compared to that in adjacent normal tissues and, in the later stage, its expression significantly increased (P<0.05). VEGF level was statistically associated with TMN stage, tumor differentiation degree and absence or presence of lymph node metastasis (P<0.05), but no significant correlation was found with gender, age, tumor site and size. In terms of CT manifestations, patients with high VEGF expression were found with >75% gastric wall invasion and enlargement of lymph nodes in more than 2 regions compared to those in the low VEGF expression group. The overall survival rate of VEGF-positive patients was significantly reduced compared to VEGF negative patients (P<0.05). Conclusion: VEGF expression is implicated in gastric cancer pathogenesis and is associated with prognosis.