4b,5,6,9-Tetrahydro-7h-Dibenzo[C,E]Pyrrolo[1,2-A]Azepin-7-One

Maksim A. Boichenko,Igor Yu Babkin,Sergey G. Kobylskoy,Alexey O. Chagarovskiy,Olga A. Ivanova,Igor Trushkov

MOLBANK（2019）

Cited 1|Views3

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Abstract

A simple approach to synthesize 4b,5,6,9-tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin- 7-one has been developed, based on a three-step transformation of 2-(2-bromophenyl)cyclopropane-1,1-diester. The key stage in this method is an intramolecular cross-coupling of 1-(2-bromobenzyl)-5-(2-bromophenyl)pyrrolidin-2-one under continuous flow conditions in an H-Cube-Pro using commercially available supported Pd catalysts.

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Key words

donor-acceptor cyclopropanes, tetrahydrodibenzo[c,e]pyrrolo[1,2-a]azepines, cross-coupling reactions, flow chemistry

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