The Expression Level Of Lncrna-Atb Associates With Clinicopathological Parameters And Prognosis Of Cervical Cancer

Background: Long noncoding RNAs (lncRNAs) play important roles in tumor development and progression. Previous studies have found that dysregulation of lncRNA-ATB was significantly associated with tumor progression and poor survival outcome in various cancers. However, whether the expression level of lncRNA-ATB is associated with the clinicopathological parameters and prognosis of patients with cervical cancer is still unclear. Methods: A total of 128 patients with primary cervical cancer were included in this retrospective study. Quantitative real-time PCR assay was performed to evaluate lncRNA-ATB expression levels. The Kaplan-Meier method was used to estimate survival, log-rank test was used to test differences between the survival curves. Results: As revealed by quantitative RT-PCR analysis, lncRNA-ATB expression was significantly higher in cervical cancer tissues compared with normal adjacent tissues (8.826 +/- 3.155 vs. 3.372 +/- 1.043, P< 0.001). High lncRNA-ATB expression level was observed to be closely correlated with tumor differentiation (P< 0.001) and FIGO stage (P< 0.001). The overall survival of patients in the high lncRNA-ATB group showed significantly worse survival rates than those who were in the low lncRNA-ATB group (P= 0.024). Furthermore, multivariate analysis of the prognosis factors with a Cox proportional hazards model showed that high lncRNA-ATB expression (HR= 2.535, CI: 1.372-10.376, P= 0.012) was a significant independent predictor of poor survival in cervical cancer. Conclusion: Our results suggested that upregulation of lncRNA-ATB was significantly correlated with tumor progression and might be a potent prognostic marker of cervical cancer.