Hypericin-Mediated Selective Photomodification Of Connective Tissues
PHOTONICS IN DERMATOLOGY AND PLASTIC SURGERY(2017)
Abstract
Hypericin (Hyp) has received attention due to its high phototoxicity against viruses and anti-tumor photoactivity. Using two-photon imaging, we demonstrated that Hyp induced photosensitized modification of collagen fibers in native tissues. Dynamics of photo-processes was monitored by time-lapse multiphoton imaging. We showed that Hyp-mediated processes in collagen tissues may be used for the selective modification of collagen fibers.
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Key words
Hypericin,collagen,SHG,biological imaging,multiphoton microscopy
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