Gross And Histopathologic Changes Of Porcine Cholecyst Assisted Full Thickness Skin Wound Healing In Rabbits

The remodeling and regenerative responses of porcine cholecyst on full thickness skin wounds were evaluated in this study. Comparison of porcine cholecyst and open wound control were made for evaluation. The in vivo evaluations were done on full thickness skin wound healing model in New Zealand White rabbits. The inflammatory, remodeling, and regenerative responses were evaluated 7, 14, 21 and 28 days post implantation. The H&E stained sections were evaluated for inflammatory and remodeling responses. The results of the current study indicated that porcine derived cholecyst scaffolds are one of the best suited materials for full thickness skin wound healing, owing to their biochemical, biodegradable, biocompatible and tissue remodelling responses. The use of porcine cholecyst in full thickness skin wounds shows improved epithelialization and faster remodelling devoid of infections or graft rejections in all the animals under study. Scab formation, ulcerations and other complications were also not observed in any of the scaffold assisted wounds.