Discover Toxicology: An Early Safety Assessment Approach
TRANSLATING MOLECULES INTO MEDICINES: CROSS-FUNCTIONAL INTEGRATION AT THE DRUG DISCOVERY-DEVELOPMENT INTERFACE(2017)
摘要
Early safety assessment efforts from target identification to lead development have undergone rapid growth and evolution over the last 10 years. In this chapter, we will discuss the current development trends driving the need for early safety assessment practices. We will discuss the key areas of focus which include target-related, off-target-related, and chemical property-related toxicities. We will offer an overview of the various scientific approaches being utilized in each of these focus areas along with an organizational framework that has proven effective in de-risking the early portfolio. We will conclude with some perspectives on application within the project team setting and traps associated with data over interpretation.
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关键词
In silico safety pharmacology, In vitro toxicology endpoint, In vivo toxicology prediction, Livery injury, Toxicogenomics, Gene editing, Microphysiological culture systems, Heart injury cell models, Injection site irritation, Skeletal muscle injury cell models, Gastrointestinal injury cell models
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