The Effects Of Ghrelin On Gh, Acth And Cortisol Release In Thyrotoxicosis
PROCEEDINGS OF THE 12TH INTERNATIONAL CONGRESS OF ENDOCRINOLOGY(2004)
Abstract
In thyrotoxicosis there is an impaired GH response to several stimuli. Ghrelin is a potent GH secretagogue and it also induces ACTH and cortisol release in men. We evaluated the effects of ghrelin in 6 hyperthyroid patients and in 8 controls. In thyrotoxicosis peak GH (mu g/L; mean +/- SE) levels after ghrelin administration were significantly lower than those observed in controls (20.9 +/- 3.5 vs. 62.6 +/- 10.3). The same pattern was seen with AUC (mu g/L.120min) values (871 +/- 141 vs. 3667 +/- 662). ACTH and cortisol levels after ghrelin injection were similar in thyrotoxic patients and controls. In summary, our data shows that ghrelin-induced GH release is decreased in thyrotoxicosis, while ACTH and cortisol responsiveness is maintained. This could suggest that thyroid hormone excess interferes with GH releasing pathways activated by ghrelin.
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