Prognostic Factors Affecting Intravenous Immunglobulin Therapy In Children Diagnosed Immune Thrombocytopenic Purpura And Effect Of Treatment On Chronicity

INTRODUCTION: Main purpose of this study is to evaluate the prognostic factors affecting intravenous immunglobulin therapy in children diagnosed immune thrombocytopenic purpura and effect of treatment on chronicity.METHODS: 80 children who are 3 months-16 years old diagnosed with immune thrombocytopenia during 2000-2016 were included in this study. The gender of each patient, age, history of infection and vaccination before diagnosis, bleeding findings, laboratory values at diagnosis, duration of response to IVIG treatment, and thrombocyte counts after 1 year were examined. Data were compared between acute and chronic ITP groups.RESULTS: Sociodemographic and laboratory characteristics of totally 80 children were evaluated. The average age of children was 71.40 +/- 46.18 months. In our cases, the ratio of male to female was 1,0. Thirty two of our cases (53.33%) had a history of viral infection within 6 weeks prior to admission. 11% of acute ITPs had a story of vaccination within 6 weeks prior to thrombocytopenia, whereas no vaccination was detected within 6 weeks of chronic ITP. Acute ITP was diagnosed in 22 cases in autumn at most, and chronic ITP was diagnosed in 7 cases in winter and summer months. Similar results were obtained when tthe mean platelet counts, WBC, MPV, PDW, PCT, CRP, PT, aPTT values of the patients were evaluated.DISCUSSION AND CONCLUSION: We need further studies on the genetic mechanism and autoantibodies in immune thrombocytopenia with respect to demographics, clinical findings, laboratory findings and treatment modalities to predict chronicity.