Amino Acids And Peptides .25. Preparation Of Fibronectin-Related Peptide Poly(Ethylene Glycol) Hybrids And Their Inhibitory Effect On Experimental Metastasis
CHEMICAL & PHARMACEUTICAL BULLETIN(1995)
Abstract
Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD) Arg-Gly-Asp-Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their inhibitory effects on experimental metastasis in mice were examined. The inhibitory effect of RGD was markedly potentiated by hybrid formation with poly(ethylene glycol) #6000. As to inhibitory effect, RGD was more potent than RGDS and RGD PEG hybrids were superior to RGDS PEG hybrids. Hybrid formation with PEG #6000 was more effective than that with PEG #4000.
MoreTranslated text
Key words
fibronectin, metastasis inhibitor, PEGylation, poly(ethylene glycol) hybrid, tumor metastasis
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined