Comparative Anatomy And Connectivity Of The Aii Amacrine Cell In Mouse And Rabbit Retina

Studying the comparative retinal anatomy of different models relevant to vision research is important for understanding how we develop therapies and cures for blinding diseases. Mouse retina structurally differs from rabbit retina, as it is thicker and vascularized, while the rabbit retina is thinner and avascular. The implications of these differences on neuronal morphology and connectivity is not yet known. This project compares the morphology and connectivity of the Aii amacrine cell (AC) with ultrastructural precision in connectomes of rabbit (RC1) and mouse (RC2) retina. The Aii amacrine cell is a crucial cell class required for night vision and involved in the switching between retinal networks from bright to dark environments and vice versa.