Predictive Value Of Dce-Mris For Tumor Regression And Sensitivity After Concurrent Chemoradiotherapy For Nasopharyngeal Carcinomas

Objective: The aim of this study was to examine the predictive value of DCE-MRI for tumor regression and sensitivity after concurrent chemoradiotherapy for nasopharyngeal carcinoma. Method: A total of 45 patients diagnosed with nasopharyngeal carcinoma, from June 2017 to December 2017, were enrolled in the study. All patients received MRI examinations before chemotherapy and were given intensity-modulated radiotherapy after 2 cycles of induction chemotherapy. Quantitative parameters before chemotherapy, at 50 Gy of radiotherapy, and at the end of radiotherapy were compared. The correlation of quantitative parameters and Regression rate during chemoradiotherapy was studied. Patients were divided into the sensitive group, efficacy intermediate group, and treatment resistant group, according to RSO and symptoms. Parameters at 50 Gy in patients with different sensitivities were compared. Results: Parameters of Ktrans, Kep, and Ve in the nasopharyngeal carcinoma area were significantly higher than those in the lateral pterygoid muscle (P<0.05). Ktrans had the highest sensitivity and Kep had the highest specificity. Ktrans and Kep values, after treatment, were significantly lower than those before treatment. Ve, after treatment, was significantly increased (P<0.05). At 50 Gy, Ktrans was negatively correlated with RSO (r=-0.613 P<0.05), Kep was negatively correlated with RSO (r= 0.626 P<0.05), and Ve was not correlated with RSO (r=0.022 P=0.887). Ktrans and Kep in the sensitive group were significantly higher than those in the efficacy intermediate group and treatment resistance group (P<0.05). Ve of the sensitive group was slightly lower than that in the efficacy intermediate group and treatment resistance group (P>0.05). Conclusion: Quantitative DEC-MRI is applicable to effectively evaluate the efficacy of chemoradiotherapy in patients with nasopharyngeal carcinoma. It can predict tumor regression and treatment sensitivity of nasopharyngeal carcinoma after treatment, providing more reliable data for efficacy assessment and prediction of nasopharyngeal carcinomas.