Ppar Gamma And Il-6-174g > C Gene Variants In Croatian Patients With Ischemic Stroke

Aim: Etiology of ischemic stroke (IS) is multifactorial and includes interaction of genetic and environmental factors. Different genes, their polymorphisms, host susceptibility, and inflammation processes play a role in IS development The aim of this study was to evaluate the effect of PPAR-gamma and IL-6 gene variants on IS onset.Material and methods: A total of 301 subjects (144 males, 157 females) participated in the study, 114 patients with IS and 187 healthy controls.Results: Statistically significant predictors of IS were male gender (OR 7.13,95% CI 2.92-17.39, p < 0.001), hypertension (OR 7.82.95% Cl 2.53-24.19, p < 0.001), lowered HDL cholesterol (OR 8.20,95% Cl 2.41-27.94, p = 0.001), elevated C-reactive protein (OR 5.26, 95% CI 1.92-14.41) and IL-6 174 GC (OR 2.44 95% Cl 1.01-5.91, p = 0.0048) genotype. Males, compared to females, had 7 times higher odds for stroke. IL6 - 174G/C genotype increased the odds for IS for 2.4 times. PPAR gamma was not statistically significantly associated with stroke.Conclusion: We can point to the IL-6 - 174G>C polymorphisms as candidate gene marker and risk factor for the prediction of ischemic stroke. (C) 2015 Elsevier B.V. All rights reserved.