Association Between Single Nucleotide Polymorphism Of N-Acetyltransferase 2 And Susceptibility To Acute Lymphoblastic Leukemia In Chinese Han Children

Aims: To investigate the association of four single nucleotide polymorphisms (SNPs) within NAT2 gene and additional gene-gene interaction with ALL risk in Chinese children. Methods: Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among 4 SNPs; Logistic regression was performed to investigate association between 4 SNPs within NAT2 gene and ALL risk and additional gene-gene interaction between rs1799931 and rs1801280. Results: The carriers of homozygous mutant or heterozygous of rs1801280, rs1799930 and rs1799931 were all associated with increased ALL risk than those with wild-type homozygotes, OR (95% CI) were 1.41 (1.12-1.89), 1.54 (1.20-1.95) and 1.76 (1.26-2.32), respectively. GMDR analysis indicated a significant interaction between rs1799931 and rs1801280 on ALL risk. Participants with rs1799931GA/AA and rs1801280-TC/CC genotype have the highest ALL risk, compared to participants with rs1799931-GG and rs1801280-TT genotype, OR (95% CI) = 3.02 (1.86-4.26). Haplotype containing the rs1799931-A and rs1799931-A allele was associated with increased ALL risk. Conclusions: We found that rs1801280, rs1799930 and rs1799931 within NAT2 gene, interaction between rs1799931 and rs1801280 and haplotype containing the rs1799931-A and rs1799931-A allele were all associated with increased ALL risk.