Relationship Between Vitamin D Deficiency And Coronary Tortuosity Severity

BACKGROUND: The purpose of the study is to investigate the frequency of serum anti-Saccharomyces cerevisiae. Serum 25-hydroxyvitamin D (vitamin D) deficiency or insufficiency has been implicated in endothelial dysfunction and cardiovascular disease via assumed mechanisms of renin-angiotensin-aldosteron system and modulation in levels of reactive oxygen species, which contribute to inflammation. Coronary tortuosity (CorT) is a common coronary angiograpic finding, though the etiology, clinical implication and long-term prognosis of the state are still not well clarified. This study was conducted with the aim to evaluate the relationship between CorT and vitamin D.METHODS: The medical records of consecutive patients, who underwent coronary angiography, were retrospectively reviewed. The study group consisted of 2156 patients. Taking into consideration the inclusion criteria, 421 patients with CorT and patients with normal or near-normal coronary arteries (<30% stenosis on quantitative coronary angiogram) were included in the study. Vitamin D, other biochemical parameters, clinical and echocardiographic parameters, and CorT were evaluated in all patients. The tortuosity score was calculated as a sum of scores for each epicardial coronary artery.RESULTS: Patients with CorT were older and female, had a more frequent history of hypertension. Vitamin D was significantly decreased in patients with CorT (134.7 +/- 47.8 vs. 239.6 +/- 53.8, P<0.001). On multivariate analysis, female gender, hypertension, vitamin D was independent predictors for CorT (OR=2.158, 95% CI : 1.825-2.638, P<0.001; OR= 1.743, 95% CI : 1.478-1.983, P<0.001; OR= 1.937, 95% CI : 1.469-2.385, P<0.001; respectively). Vitamin D level was also significantly negatively correlated with CorT severity (r= 0.850, P<0.001).CONCLUSIONS: In our study, we have found a significant relationship between vitamin D deficiency and CorT severity.