Spinal Stenosis Associated With Php-La: A Case Report And Literature Review

Pseudohypoparathyroidism type la (PHP-la) is an extremely rare hereditary disorder. We report the case of a 33-year-old male with PHP-la and typical Albright hereditary osteodystrophy phenotype, with complaints of paraparesis due to extensive cervical spinal stenosis. The spinal stenosis was caused by diffused ossification of the posterior longitudinal ligament and multilevel intervertebral disc herniation. It is a rare but important manifestation of PHP-la that is being increasingly reported. This report aimed to highlight the relationship between spinal stenosis and PHP-la through extensive literature review and recommends that all patients with evident neurological symptoms due to spondylopathy should be screened for serum calcium, phosphate and PTH level to rule out PHP. Moreover, early diagnosis and timely corrections of hypocalcemia, hyperphosphatemia and elevated PTH level as well as effective body weight control are important to prevent rare neurological complications in patients with PHP-la.