Anesthetic Effect Of Butorphanol Tartrate Combined With Dezocine In Hysteroscopic Surgery

Objective: Our aim was to investigate the sedative and analgesic effects of butorphanol tartrate combined with dezocine in hysteroscopic surgery. Methods: A total of 160 patients who voluntarily opted for hysteroscopic surgery in our hospital were randomized to fentanyl + propofol group with 40 cases (group A), butorphanol tartrate + propofol group with 40 cases (group B), dezocine + propofol group with 40 cases (group C), and butorphanol tartrate + dezocine + propofol group with 40 cases (group D). The fluctuation of mean arterial pressure (MAP), heart rate (HR), and respiratory (RR) were observed and recorded before the operation (T-0), after the induction (T-1), during the cervical dilatation (T-2), and after the operation (T-3). The number of patients with SpO(2)<90% during the operation was recorded. The anesthetic effect during the surgery, the total dose of propofol, postoperative awake time, postoperative contraction pain score (VAS), and adverse reactions in the postoperative period such as nausea, vomiting, dizziness, excitement, and restlessness were all documented. Results: No distinctive difference was found in MAP, HR, and RR among these four groups at T-0 and T-3 (all P>0.05). Declines were observed in all groups at T-1 (all P<0.05) and a more pronounced decrease was seen in group A (P<0.05). At T-2, the MAP, HR, and RR of group B and group C were noticeably higher than those of group A and group D (P<0.05). The number of patients with SpO(2)<90% in group A was markedly higher than that in group B, group C, and group D (P<0.05) while the number of patients with movement responses during the operation in group A and group D was much less than that in group B and group C (P<0.05). The total dose of propofol used in group A and group D was prominently less than that in group B and group C (P<0.05). There was no notable change in awake time in group B, group C, and group D but they were all apparently shorter than those in group A (all P<0.05). Postoperative VAS scores in group A and group D were markedly lower than those in group B and group C (P<0.05) and adverse reactions in the postoperative period such as nausea and vomiting in group D were apparently less than those in group A (P<0.05). Conclusion: The analgesic effect of butorphanol tartrate in combination with dezocine in hysteroscopic surgery is not only better than a single use of butorphanol tartrate or dezocine but also can achieve an equivalent sedative, analgesic, and anesthetic effect of fentanyl. Furthermore, respiratory depression, postoperative awake time, and adverse reactions in the postoperative period in patients show an outstanding benefit compared to those with fentanyl. Hence, it proves that butorphanol tartrate combined with dezocine can achieve potent anesthetic effects with less adverse reactions in hysteroscopic surgery.