Clinicopathological Features Of Primary Myoepithelial Carcinoma Inside Oblique Eminence Of Cuboid Bone: A Case Report

Primary intraosseous myoepithelial carcinomas are extremely rare tumors. It is important to make an accurate pathological diagnosis for timely and proper treatment. We evaluated imaging, histological, and immunohistochemical studies of a new case and performed a comprehensive review of the related literature. Plain and enhanced scan CT showed that the left proximal femur had an osteolytic lesion and speckled calcification, inhomogeneous enhancement was also observed after reinforcement. Microscopically, multinodular tumors were comprised mostly of polygonal cells within a stroma containing a variable amount of myxoid, chondroid, hyalinized, and osteoid-like material. Through immunohistochemistry, the tumor cells had diffuse strong staining for CK, P63, and P16. The Ki-67 index was less than 10%. We conclude that correct diagnosis must be achieved by imaging, histological, and immunohistochemical stains. Primary intraosseous myoepithelial carcinoma also should be distinguished from metastatic myoepithelial carcinomas from the salivary gland, conventional osteosarcoma, and epithelial/cartilaginous differentiation in clear cell chondrosarcoma.